Republican Eric Holcomb defeated Democrat John R. Gregg to become the new governor of Indiana. Holcomb, currently serving as the Lt. Gov., replaced Vice President-elect Mike Pence as the Republican gubernatorial nominee on July 27, 2016.

Additionally, Indiana voters approved the only ballot measure on the November ballot. Public Question 1, also known as the Right to Hunt and Fish Amendment, made it a constitutional right to hunt and fish. Indiana is the 20th state to establish hunting and fishing as a constitutional right.